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The frontier · research surface

The map of what we don't know.

A dashboard of everything Sniff can't answer yet, and, for each gap, why. "We don't know" is worthless; "this gene is dark because nobody has studied it in people, versus its evidence is too weak, versus there's no dog ortholog at all" is a citable map. Of the … genes the dog↔human bridge touches, only … have a strong (reachable + 3★) human-disease-model foundation. Those are the candidate models Sniff champions; the rest is the frontier, categorized below.

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… genes

The hard wall: the ortholog gap

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This is the sourced answer to a number that used to float around unsourced, computed from our own reverse orthology, not a slide. "Unreachable" means no dog ortholog via the full ladder (Compara one2one OR the moderate OrthoDB/OMA ladder), so PCSK9 is the exemplar. BRCA2 and VHL are actually reachable via the ladder that pure one2one misses.

The candidates are the light; this is the shadow. The genes that did clear the evidence stack are the candidate models; strike any node in Spectra. This surface is the honest map of everything that didn't, and why.

Two grains, never double-counted. The gene-grain frontier (unstudied / below-bar / unreachable) is above; the variant/coordinate-grain funnel (position-only, no-phyloP) is the exhaustive scan section.

Sources: ClinVar gene-disease anchors · Ensembl Compara + OrthoDB/OMA orthology.