NKX2-8
NKX2-8 is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
NKX2-8 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is NKX2-8. That ortholog is what connects NKX2-8 to a century of human medical genetics. The dog and human proteins are 87% identical.
In people, NKX2-8 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 1.93). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For NKX2-8 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.