Reverse query / human → dog
central core myopathy.
Which dogs are a natural model of this human disease. Each row is a distinct gene pathway with a canine model, ranked by evidence strength. We assert the canine disease models the human one (gene-level), never that a dog allele equals a human variant.
| Canine model pathway | Evidence | Ortholog | Human anchor | Canine variant · assembly |
|---|---|---|---|---|
| RYR1 → RYR1 3★ anchor | ★★★ ClinVar · 21 P/LP | high 96.43% | OMIM 117000 | chr1:115309510 C>GUU_Cfam_GSD_1.0 |
The boundary of this model. The rows above are the characterized
pathways, human genes of this disease with a canine model in our substrate.
The panel of established genes is joined from GenCC, so covered and uncovered genes are both named. A gene can still be a cause of this disease at below-established validity, or through a mechanism no gene panel captures.