Reverse query / human → dog
congenital factor XI deficiency.
Congenital factor XI deficiency is an inherited bleeding disorder characterized by reduced levels and activity of factor XI (FXI) resulting in moderate bleeding symptoms, usually occurring after trauma or surgery.
Which dogs are a natural model of this human disease. Each row is a distinct gene pathway with a canine model, ranked by evidence strength. We assert the canine disease models the human one (gene-level), never that a dog allele equals a human variant.
| Canine model pathway | Evidence | Ortholog | Human anchor | Canine variant · assembly |
|---|---|---|---|---|
| F11 OMIA model-of | OMIA-anchored | no_human_ortholog | — | gene-level (no single variant) |
| — OMIA model-of | OMIA-anchored | one2one | — | gene-level (no single variant) |
Established genes without a canine model yet
Of the 1 genes GenCC calls an established (Definitive / Strong / Moderate) cause of congenital factor XI deficiency, these 1 do not have a canine natural model in our substrate yet. Not "no dog carries this", a stated gap in what we hold, the honest frontier of the reverse query.
Gene-disease validity from GenCC (thegencc.org, CC0), the established tail across ClinGen, OMIM, Orphanet, and others. Each gene links to its Sniff lookup, where the human ortholog and any canine evidence we hold are shown, gene-level (INV-57).