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Reverse query / human → dog

dilated cardiomyopathy 1NN.

Which dogs are a natural model of this human disease. Each row is a distinct gene pathway with a canine model, ranked by evidence strength. We assert the canine disease models the human one (gene-level), never that a dog allele equals a human variant.

1 model pathway 0 OMIA-anchored 1 of 1 disease genes modeled MONDO:0014396 ↗ OMIM 615916 ↗
Canine model pathway Evidence Ortholog Human anchor Canine variant · assembly
RAF1 → RAF1 3★ anchor ★★★ ClinVar · 1 P/LP high-corroborated 98.77% OMIM 615916 chr20:6040929 C>TUU_Cfam_GSD_1.0
The boundary of this model. The rows above are the characterized pathways, human genes of this disease with a canine model in our substrate. The panel of established genes is joined from GenCC, so covered and uncovered genes are both named. A gene can still be a cause of this disease at below-established validity, or through a mechanism no gene panel captures.
A candidate model is a computational hypothesis (gene-level model-of, INV-57), never a confirmed model; confirmation is DNA plus phenotype, in the lab. Canine coordinates are on UU_Cfam_GSD_1.0 and carry their assembly (no cross-assembly comparison without a scored liftover). Sources: OMIA, ClinVar (Landrum 2018), Ensembl Compara orthology, Mondo. Ranked by evidence strength within this human disease.