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Cancer-driver node · fused signature

KDR

Every register Sniff holds about KDR, in one place, each strand cited to its source. This is a gene-level, model-of view of somatic cohort frequencies and human evidence, never a germline carrier status for an individual dog and never a per-dog prediction.

Somatic driver in canine cancer

The fraction of sequenced tumors somatically altered in KDR, per cancer, from peer-reviewed cohorts. A cohort rate, not an individual-dog risk. Each cancer carries its cross-species concordance: whether the dog and human agree on this driver (commensurability-gated, INV-81). KDR diverges from human in 1 of these 1, the honest limit of the model.

Translational evidence balance
balanced · 0

Dog and human evidence are symmetric. A validated cross-species footprint. Coverage, not importance. D = 1 dog vs H = 1 human cited disease channels.

Human constraint
LOEUF 0.328
constrained (LoF-intolerant) · gnomAD v4.1
Germline (human)
no germline syndrome (a true negative, not a gap)
Dog↔human ortholog
high-corroborated
5 methods · 92.99% identity