DNM2
DNM2 is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
DNM2 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is DNM2. That ortholog is what connects DNM2 to a century of human medical genetics. The dog and human proteins are 93% identical.
In people, DNM2 rarely tolerates loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.24), a sign it does important, dosage-sensitive work.
In people, variants in the DNM2 gene are classified as pathogenic in ClinVar for 5 expert-reviewed conditions.
In dogs, 30 of 2,213 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.
The human literature carries more cited disease evidence than the dog side, a study gap on the canine side. Coverage, not importance. D = 0 dog vs H = 2 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For DNM2 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.