GRM1
GRM1 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.
The inherited conditions OMIA associates with GRM1 in dogs. Each links to the full record.
GRM1 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is GRM1. That ortholog is what connects GRM1 to a century of human medical genetics. The dog and human proteins are 95% identical.
In people, GRM1 rarely tolerates loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.42), a sign it does important, dosage-sensitive work.
In people, variants in the GRM1 gene have conflicting classifications in ClinVar, and none is expert-reviewed. The evidence is unsettled, not that variants here are benign.
In dogs, 54 of 9,896 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.
The human literature carries more cited disease evidence than the dog side, a study gap on the canine side. Coverage, not importance. D = 1 dog vs H = 2 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces (1 surfaced Dog10K candidate name this gene; never confirmed). Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For GRM1 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.