GUCY2D
GUCY2D is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
GUCY2D as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is GUCY2D. That ortholog is what connects GUCY2D to a century of human medical genetics. The dog and human proteins are 87% identical.
In people, GUCY2D appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.91). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
In people, variants in the GUCY2D gene are classified as pathogenic in ClinVar for 7 expert-reviewed conditions.
In dogs, 25 of 434 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.
Dog and human evidence are symmetric here, a validated cross-species footprint. Coverage, not importance. D = 1 dog vs H = 1 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For GUCY2D we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.