PTEN
PTEN is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
PTEN as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is PTEN. That ortholog is what connects PTEN to a century of human medical genetics. The dog and human proteins are 100% identical.
In people, PTEN appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.69). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
In people, variants in the PTEN gene are classified as pathogenic in ClinVar for 14 expert-reviewed conditions.
In dogs, 12 of 1,610 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.
The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 2 dog vs H = 1 human cited disease channels.
PTEN is a fused cancer-driver node. See its somatic role across canine cancers, human gnomAD constraint, germline ClinVar syndromes, and the dog-human ortholog in one cited view. Open the driver node →
Lookup and discovery are candidate-framed research surfaces (1 surfaced Dog10K candidate name this gene; never confirmed). Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For PTEN we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.